Higher vs lower doses of dexamethasone in patients with COVID‐19 and severe hypoxia (COVID STEROID 2) trial: Protocol and statistical analysis plan

Author:

Munch MW12ORCID,Granholm Anders12,Myatra SN3,Vijayaraghavan BKT456,Cronhjort Maria7,Wahlin RR7,Jakob Stephan M.8,Cioccari Luca8,Kjær MN12ORCID,Vesterlund GK12ORCID,Meyhoff TS12ORCID,Helleberg Marie9,Møller MH12ORCID,Benfield Thomas10,Venkatesh Balasubramanian11,Hammond Naomi11,Micallef Sharon11,Bassi Abhinav6,John Oommen612,Jha Vivekanand61213,Kristiansen KT14,Ulrik CS15,Jørgensen VL16,Smitt Margit17,Bestle Morten H.1819,Andreasen AS20,Poulsen LM21,Rasmussen BS222ORCID,Brøchner AC23,Strøm Thomas2425,Møller Anders26,Khan MS27,Padmanaban Ajay45,Divatia JV3,Saseedharan Sanjith28,Borawake Kapil29,Kapadia Farhad30,Dixit Subhal31,Chawla Rajesh32,Shukla Urvi33,Amin Pravin34,Chew Michelle S.35,Gluud Christian36,Lange Theis37,Perner Anders12ORCID

Affiliation:

1. Department of Intensive Care, Rigshospitalet University of Copenhagen Copenhagen Denmark

2. Collaboration for Research in Intensive Care (CRIC) Copenhagen Denmark

3. Department of Anaesthesia Critical Care and Pain, Tata Memorial Hospital, Homi Bhabha National Institute Mumbai India

4. Department of Critical Care Apollo Hospitals Chennai India

5. Chennai Critical Care Consultants Chennai India

6. The George Institute for Global Health, University of New South Wales New Delhi India

7. Department of Clinical Science and Education, Södersjukhuset Karolinska Institutet Stockholm Sweden

8. Department of Intensive Care Medicine Inselspital, Bern University Hospital, University of Bern Bern Switzerland

9. Department of Infectious Diseases, Rigshospitalet University of Copenhagen Copenhagen Denmark

10. Department of Infectious Diseases, Center of Research & Disruption of Infectious Diseases Copenhagen University Hospital – Amager and Hvidovre Copenhagen Denmark

11. The George Institute for Global Health, University of New South Wales Sydney New South Wales Australia

12. Prasanna School of Public Health Manipal Academy of Higher Education Manipal India

13. School of Public Health Imperial College London London UK

14. Department of Anaesthesia and Intensive Care Hvidovre Hospital, University of Copenhagen Copenhagen Denmark

15. Department of Respiratory Medicine Hvidovre Hospital, University of Copenhagen Copenhagen Denmark

16. Department of Thoracic Anaesthesiology, Rigshospitalet University of Copenhagen Copenhagen Denmark

17. Department of Neuroanaesthesiology, Rigshospitalet University of Copenhagen Copenhagen Denmark

18. Department of Anaesthesiology and Intensive Care Copenhagen University Hospital Nordsjælland Denmark

19. Department of Clinical Medicine University of Copenhagen Copenhagen Denmark

20. Department of Anaesthesia and Intensive Care Herlev Hospital, University of Copenhagen Copenhagen Denmark

21. Department of Anaesthesiology Zealand University Hospital Copenhagen Denmark

22. Department of Anaesthesia and Intensive Care Aalborg University Hospital Aalborg Denmark

23. Department of Anaesthesia and Intensive Care Kolding Hospital Kolding Denmark

24. Department of Anaesthesia and Critical Care Medicine Odense University Hospital Odense C Denmark

25. Department of Anaesthesia and Critical Care Medicine Hospital Sønderjylland, University Hospital of Southern Denmark Odense Denmark

26. Department of Anaesthesia and Intensive Care Næstved‐Slagelse‐Ringsted Hospital Slagelse Denmark

27. Department of Critical Care Medicine Rajendra Institute of Medical Sciences Ranchi India

28. Department of Intensive Care SL Raheja Hospital Mumbai Maharashtra India

29. Department of Intensive Care Vishwaraj Hospital Pune India

30. Section of Critical Care, Department of Medicine Hinduja Hospital Mahim, Mumbai India

31. Department of Critical Care Medicine Sanjeevan Hospital Pune Maharashtra India

32. Department of Respiratory and Critical Care Medicine Indraprastha Apollo Hospital New Delhi India

33. Intensive Care Unit and Emergency Services Symbiosis University Hospital and Research Centre Lavale, Pune India

34. Department of Critical Care Medicine Bombay Hospital Institute of Medical Sciences Mumbai India

35. Department of Anesthesiology and Intensive Care, Biomedical and Clinical Sciences Linköping University Linköping Sweden

36. Copenhagen Trial Unit, Centre for Clinical Intervention Research Capital Region of Denmark, Rigshospitalet, Copenhagen University Hospital Copenhagen Denmark

37. Department of Public Health, Section of Biostatistics University of Copenhagen Copenhagen Denmark

Funder

Rigshospitalet

Novo Nordisk Fonden

Publisher

Wiley

Subject

Anesthesiology and Pain Medicine,General Medicine

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