Retrospective first‐in‐human use of the LithoVue™ Elite ureteroscope to measure intrarenal pressure

Abstract

ObjectiveTo report on our first‐in‐human experience using the LithoVue Elite™ ureteroscope (Boston Scientific Corp., Marlborough, MA, USA) to measure intrarenal pressure (IRP) during flexible ureteroscopy.Patients and MethodsA single‐arm retrospective observational analysis was performed in 50 consecutive patients undergoing ureteroscopic lithotripsy using the LithoVue Elite™ system with pressure sensing capability between April 2022 and February 2023 at two centres. A pressure bag set at 150 mmHg or hand irrigation with a 60‐mL syringe was used for irrigation and a ureteric access sheath (UAS) was placed at the physician's discretion. Median and maximum IRPs, and relative cumulative time exceeding 20, 40, 60, 80, 100, 120, 140, 160, and 200 mmHg per total procedure time were analysed. The two‐sample Mann–Whitney U‐test was used, with statistical significance set at P < 0.05.ResultsThe median (interquartile range [IQR]) patient age and body mass index (BMI) was 62.5 (46.7–68.2) years and 27.6 (23.3–32.1) kg/m2, respectively. During the median (IQR) total procedure time of 31.9 (17.4–44.9) min, the median and maximum IRPs were 28.5 (20.0–47.5) and 174.0 (133.5–266.0) mmHg, respectively. IRP remained at <60 mmHg during 92% of the procedure times. Patients with Asian ethnicity, and those without pre‐stenting or UAS use exhibited longer cumulative/total durations exceeding pre‐defined IRP cut‐off values. The smaller 10/12‐F UAS did not lower pressures as much as the 11/13‐F or 12/14‐F UAS (P < 0.001). Age, diabetes, hypertension, preoperative α‐blockade, stone size, and BMI did not show any statistically significant associations with IRP.ConclusionsThe IRP can now be routinely measured during ureteroscopy. Patients had a median IRP of 28.5 mmHg and a maximum of 174 mmHg. Using a smaller UAS (10/12 F), Asian ethnicity, and tight ureters were found to have higher IRPs.