Implementing a pragmatic clinical trial to tailor opioids for acute pain on behalf of the IGNITE ADOPT PGx investigators

Author:

Cavallari Larisa H.1ORCID,Cicali Emily1,Wiisanen Kristin2,Fillingim Roger B.2,Chakraborty Hrishikesh3,Myers Rachel A.4,Blake Kathryn V.5ORCID,Asiyanbola Bolanle6,Baye Jordan F.7,Bronson Wesley H.8,Cook Kelsey J.59ORCID,Elwood Erica N.1,Gray Chancellor F.10,Gong Yan1ORCID,Hines Lindsay11,Kannry Joseph12,Kucher Natalie13,Lynch Sheryl14,Nguyen Khoa A.1,Obeng Aniwaa Owusu12,Pratt Victoria M.1516,Prieto Hernan A.10,Ramos Michelle17,Sadeghpour Azita4,Singh Rajbir18,Rosenman Marc1920,Starostik Petr21,Thomas Cameron D.1ORCID,Tillman Emma14,Dexter Paul R.19,Horowitz Carol R.1217,Orlando Lori A.4,Peterson Josh F.22,Skaar Todd C.14,Van Driest Sara L.23ORCID,Volpi Simona13,Voora Deepak4ORCID,Parvataneni Hari K.10ORCID,Johnson Julie A.1,

Affiliation:

1. Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics and Precision Medicine College of Pharmacy, University of Florida Gainesville Florida USA

2. Department of Community Dentistry and Behavioral Science, College of Dentistry University of Florida Gainesville Florida USA

3. Department of Biostatistics and Bioinformatics Duke University Durham North Carolina USA

4. Duke Center for Applied Genomics & Precision Medicine Duke University Durham North Carolina USA

5. Center for Pharmacogenomics and Translational Research Nemours Children's Health Jacksonville Florida USA

6. Department of Surgery Meharry Medical College Nashville Tennessee USA

7. Imagenetics, Sanford Health Sioux Falls South Dakota USA

8. Department of Orthopaedic Surgery Icahn School of Medicine at Mount Sinai New York New York USA

9. Department of Pharmacotherapy and Translational Research, College of Pharmacy University of Florida Jacksonville Florida USA

10. Department of Orthopaedic Surgery, College of Medicine University of Florida Gainesville Florida USA

11. Brain and Spine Center Sanford Health Fargo North Dakota USA

12. Department of Medicine Icahn School of Medicine at Mount Sinai New York New York USA

13. Division of Genomic Medicine National Human Genome Research Institute, NIH Bethesda Maryland USA

14. Division of Clinical Pharmacology Indiana University School of Medicine Indianapolis Indiana USA

15. Department of Medical and Molecular Genetics Indiana University School of Medicine Indianapolis Indiana USA

16. Optum Genomics Minnetonka MN USA

17. Department of Population Health Science and Policy and Institute for Health Equity Research Icahn School of Medicine at Mount Sinai New York New York USA

18. Meharry Medical College Nashville Tennessee USA

19. School of Medicine Indiana University Indianapolis Indiana USA

20. Ann & Robert H. Lurie Children's Hospital of Chicago and Institute of Public Health, Feinberg School of Medicine Northwestern University Chicago Illinois USA

21. Department of Pathology, College of Medicine University of Florida Gainesville Florida USA

22. Departments of Biomedical Informatics and Medicine Vanderbilt University, Medical Center Nashville Tennessee USA

23. Departments of Pediatrics and Medicine Vanderbilt University Medical Center Nashville Tennessee USA

Funder

National Institutes of Health

Publisher

Wiley

Subject

General Pharmacology, Toxicology and Pharmaceutics,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Neuroscience

Reference45 articles.

1. Centers for Disease Control and Prevention.Drug Overdose. US Opioid Dispensing Rate Map.https://www.cdc.gov/drugoverdose/rxrate‐maps/index.html. Accessed January 3 2022.

2. Trends in Opioid Analgesic–Prescribing Rates by Specialty, U.S., 2007–2012

3. Opioid Prescribing After Surgery in the United States, Canada, and Sweden

4. ClinCalc DrugStats Database.The top 200 drugs of 2019.https://clincalc.com/DrugStats/. Accessed February 10 2022.

5. Preclinical and Clinical Pharmacology of Hydrocodone for Chronic Pain: A Mini Review

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