T rypanosoma brucei ( UMP synthase null mutants) are avirulent in mice, but recover virulence upon prolonged culture in vitro while retaining pyrimidine auxotrophy-Reference-Cited by-同舟云学术

T rypanosoma brucei ( UMP synthase null mutants) are avirulent in mice, but recover virulence upon prolonged culture in vitro while retaining pyrimidine auxotrophy

Published:2013-09-09 Issue:2 Volume:90 Page:443-455
ISSN:0950-382X
Container-title:Molecular Microbiology
language:en
Short-container-title:Molecular Microbiology

Author:

Ong Han B.¹,Sienkiewicz Natasha¹,Wyllie Susan¹,Patterson Stephen¹,Fairlamb Alan H.¹

Affiliation:

1. Divisional of Biological Chemistry and Drug Discovery College of Life Sciences University of Dundee Dundee DD1 5EH UK

Publisher

Wiley

Subject

Molecular Biology,Microbiology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/mmi.12376

Reference36 articles.

1. Clathrin-mediated endocytosis is essential in Trypanosoma brucei

2. Pyrimidine Salvage in Trypanosoma brucei Bloodstream Forms and the Trypanocidal Action of Halogenated Pyrimidines

3. Pyrimidine Biosynthesis Is Not an Essential Function for Trypanosoma brucei Bloodstream Forms

4. High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome

5. Characterization of Trypanosoma brucei dihydroorotate dehydrogenase as a possible drug target; structural, kinetic and RNAi studies

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