Pegylated interferons Lambda-1a and alfa-2a display different gene induction and cytokine and chemokine release profiles in whole blood, human hepatocytes and peripheral blood mononuclear cells

Author:

Freeman J.1,Baglino S.2,Friborg J.3,Kraft Z.1,Gray T.1,Hill M.1,McPhee F.3,Hillson J.1,Lopez-Talavera J. C.3,Wind-Rotolo M.2

Affiliation:

1. Zymogenetics; Bristol Myers-Squibb; Seattle WA USA

2. Bristol Myers-Squibb Research and Development; Lawrenceville NJ USA

3. Bristol Myers-Squibb Research and Development; Wallingford CT USA

Funder

Bristol Myers Squibb

Publisher

Wiley

Subject

Virology,Infectious Diseases,Hepatology

Reference25 articles.

1. American Association for the Study of Liver Diseases. Diagnosis, management, and treatment of hepatitis C: an update;Ghany;Hepatology,2009

2. Ribavirin: current role in the optimal clinical management of chronic hepatitis C;Reddy;J Hepatol,2009

3. Food and Drug Administration PEGASYS (peginterferon alfa-2a) label http://www.accessdata.fda.gov/drugsatfda_docs/label/2002/pegihof120302LB.pdf

4. Food and Drug Administration Copegus (ribavirin) label 2012

5. The type-I interferon receptor. The long and short of it;Domanski;Cytokine Growth Factor Rev,1996

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