Effective Interferon Lambda Treatment Regimen To Control Lethal MERS-CoV Infection in Mice

Author:

Dijkman Ronald12,Verma Abhishek Kumar3,Selvaraj Muneeswaran4,Ghimire Roshan4,Gad Hans Henrik5,Hartmann Rune5,More Sunil4,Perlman Stanley3ORCID,Thiel Volker12,Channappanavar Rudragouda43ORCID

Affiliation:

1. Institute of Virology and Immunology, Bern, Switzerland

2. Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland

3. Department of Microbiology and Immunology, University of Iowa, Iowa City, Iowa, USA

4. Department of Veterinary Pathobiology, Oklahoma State University, Stillwater, Oklahoma, USA

5. Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark

Abstract

Effective antiviral agents are urgently required to prevent and treat individuals infected with SARS-CoV-2 and other emerging viral infections. The COVID-19 pandemic has catapulted our efforts to identify, develop, and evaluate several antiviral agents.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Reference81 articles.

1. Epidemiology, Genetic Recombination, and Pathogenesis of Coronaviruses

2. Coronavirus Infection in Acute Lower Respiratory Tract Disease of Infants

3. Coronaviridae

4. World Health Organization. Regional Office for the Eastern mediterranian. 2022. http://www.emro.who.int/health-topics/mers-cov/mers-outbreaks.html.

5. World Health Organization. 2022. World coronavirus (COVID-19) dashboard. World Health Organization Geneva Switzerland. https://covid19.who.int.

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