Streptococcal dTDP‐L‐rhamnose biosynthesis enzymes: functional characterization and lead compound identification-Reference-Cited by-同舟云学术

Streptococcal dTDP‐L‐rhamnose biosynthesis enzymes: functional characterization and lead compound identification

Published:2019-01-31 Issue:4 Volume:111 Page:951-964
ISSN:0950-382X
Container-title:Molecular Microbiology
language:en
Short-container-title:Mol Microbiol

Author:

van der Beek Samantha L.¹,Zorzoli Azul²,Çanak Ebru¹,Chapman Robert N.³,Lucas Kieron²,Meyer Benjamin H.²,Evangelopoulos Dimitrios⁴,de Carvalho Luiz Pedro S.⁴,Boons Geert‐Jan³⁵,Dorfmueller Helge C.²,van Sorge Nina M.¹^ORCID

Affiliation:

1. Department of Medical Microbiology University Medical Center Utrecht, Utrecht University Heidelberglaan 1003584 CXUtrecht The Netherlands

2. Division of Molecular Microbiology, School of Life Sciences University of Dundee Dow StreetDD1 5EHDundee UK

3. Department of Chemistry, Complex Carbohydrate Research Center The University of Georgia 315 Riverbend RoadAthens USA

4. Mycobacterial Metabolism and Antibiotic Research Laboratory The Francis Crick Institute London UK

5. Department of Medical Chemistry and Chemical Biology, Utrecht Institute Pharmaceutical Science University Utrecht Utrecht 3508 TBThe Netherlands

Funder

Cancer Research UK

Wellcome Trust

Medical Research Council

Publisher

Wiley

Subject

Molecular Biology,Microbiology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/mmi.14197

Reference53 articles.

1. Comparative bioinformatics analysis of the mammalian and bacterial glycomes

2. The crystal structure of dTDP-d-glucose 4,6-dehydratase (RmlB) from Salmonella enterica serovar typhimurium, the second enzyme in the dTDP-l-rhamnose pathway

3. Toward a Structural Understanding of the Dehydratase Mechanism

4. Novel inhibitors of an emerging target in Mycobacterium tuberculosis; substituted thiazolidinones as inhibitors of dTDP-rhamnose synthesis

5. GacA is essential for Group AStreptococcusand defines a new class of monomeric dTDP-4-dehydrorhamnose reductases (RmlD)

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