Dietary chamomile flowers extract improved performance and mitigated aflatoxin B1 toxicity in rabbits

Author:

Rashad Mahmoud Gamal1,Arafa Mahmoud Mohamed2,El‐Zanaty Abd Elfattah Ibrahim3,El‐Saeed Lasheen Mohamed1,El‐Ashram Saeed Abdelalim45,Al‑Olayan Ebtesam Mohamed6,Hegazy Mostafa Mahmoud78,Farouk Mohammed Hamdy1ORCID

Affiliation:

1. Animal Production Department, Faculty of Agriculture Al‐Azhar University Cairo Egypt

2. Department of Biochemistry, Toxicology and Feed Deficiency, Animal Health Research Institute Agricultural Research Center, Dokki Giza Egypt

3. Department of Poultry Disease Diagnosis and Research, Animal Health Research Institute Agricultural Research Center, Dokki Giza Egypt

4. Department of Zoology, Faculty of Science Kafrelsheikh University Kafr El‐Sheikh Egypt

5. Microbiology Department, College of Life Science and Engineering Foshan University Foshan Guangdong China

6. Department of Zoology, College of Science King Saud University Riyadh Saudi Arabia

7. Department of Pharmacognosy and Medicinal Plants, Faculty of Pharmacy Al‐Azhar University Cairo Egypt

8. Department of Pharmacognosy, Faculty of Pharmacy Sinai University—Arish Branch Arish Egypt

Abstract

AbstractAflatoxin B1 (AFB1) is among the poisonous mycotoxins that contaminate food and feed. Limited studies are available on the efficacy of chamomile (Cha) against oxidative stress, liver damage and pro‐inflammatory response induced by AFB1. The present study aims to evaluate the effects of Cha on the performance and protective effects against AFB1 in growing rabbits. The experimental rabbits were divided into four different groups, including Cha (70 mg kg day−1), AFB1 (AF; 30 μg kg day−1), AFB1+Cha (AFLCha) and control (CON). The results indicated that the AFB1 treatment had lower values of performance, and carcass parameters compared to the Cha and AFLCha treatments. Furthermore, the Cha and AFLCha groups had lower values of liver and kidney function activities compared to the AFB1 treatment. The higher values of antioxidant enzymes were observed in Cha and AFLCha treatments than in the AFB1 treatment. AFB1 treatments had higher levels of malondialdehyde and liver functions with lower levels of antioxidant enzymes (glutathione and superoxide dismutase) compared to Cha and CON groups. In conclusion, dietary Cha could mitigate the oxidative stress of AFB1‐induced liver deterioration.

Publisher

Wiley

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Detoxification of Aflatoxin B1 by Phytochemicals in Agriculture and Food Science;Journal of Agricultural and Food Chemistry;2024-06-19

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