Safety of zidovudine dose reduction in treatment-naïve HIV infected patients. A randomized controlled study (MiniZID)

Author:

Rougemont M1,Nchotu Ngang P2,Stoll B3,Delhumeau C1,Hill A4,Ciaffi L1,Bonnet F5,Menga G2,Fampou J-C2,Calmy A1

Affiliation:

1. HIV Unit; Division of Infectious Diseases; Department of Internal Medical Specialties; Geneva University Hospitals; Geneva Switzerland

2. National Social Insurance Hospital; Approved Treatment Center; Yaounde Cameroon

3. Institute of Global Health; Faculty of Medicine; University of Geneva; Geneva Switzerland

4. Pharmacology Research Laboratories; University of Liverpool; Liverpool UK

5. CHU de Bordeaux; Service de Médecine Interne et Maladies Infectieuses & INSERM U897; Université de Bordeaux; Bordeaux France

Funder

ViiV Healthcare

Gilead Sciences

AbbVie

Meso Scale Diagnostics

Bill and Melinda Gates Foundation

‘Projet de Recherche et Développement’ of the University of Geneva Hospitals

Publisher

Wiley

Subject

Pharmacology (medical),Infectious Diseases,Health Policy

Reference25 articles.

1. Dose optimisation: a strategy to improve tolerability and lower antiretroviral drug prices in low and middle income countries;Hill;Open Infect Dis J,2010

2. Efficacy of 400 mg efavirenz versus standard 600 mg dose in HIV-infected, antiretroviral-naive adults (ENCORE1): a randomised, double-blind, placebo-controlled, non-inferiority trial;ENCORE1 Study Group;Lancet,2014

3. Optimising the manufacture, formulation, and dose of antiretroviral drugs for more cost-efficient delivery in resource-limited settings: a consensus statement;Crawford;Lancet Infect Dis,2012

4. Hicks C Haas D Seekins D et al A Phase II, double blind, placebo controlled, dose-ranging study to assess the antiretroviral activity and safety of efavirenz (DMP-266) in combination with open-label AZT with lamivudine at 24 weeks (DMP 266-005) 5th Conference on Retroviruses and Opportunistic Infections 1998

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