Repurposing Human PDE4 Inhibitors for Neglected Tropical Diseases. Evaluation of Analogs of the Human PDE4 Inhibitor GSK-256066 as Inhibitors of PDEB1 ofTrypanosoma brucei-Reference-Cited by-同舟云学术

Repurposing Human PDE4 Inhibitors for Neglected Tropical Diseases. Evaluation of Analogs of the Human PDE4 Inhibitor GSK-256066 as Inhibitors of PDEB1 ofTrypanosoma brucei

Published:2014-11-18 Issue:5 Volume:85 Page:549-564
ISSN:1747-0277
Container-title:Chemical Biology & Drug Design
language:en
Short-container-title:Chem Biol Drug Des

Author:

Ochiana Stefan O.¹,Bland Nicholas D.²,Settimo Luca¹,Campbell Robert K.²,Pollastri Michael P.¹

Affiliation:

1. Department of Chemistry and Chemical Biology; Northeastern University; 417 Egan Research Center, 360 Huntington Avenue Boston MA 02115 USA

2. Marine Biological Laboratory; Josephine Bay Paul Center for Comparative Molecular Biology and Evolution; 7 MBL Street Woods Hole MA 02543 USA

Funder

National Institute of Allergy and Infectious Diseases

Publisher

Wiley

Subject

Molecular Medicine,Biochemistry,Drug Discovery,Pharmacology,Organic Chemistry

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1111/cbdd.12443/fullpdf

Reference32 articles.

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3. Arsenicals (melarsoprol), pentamidine and suramin in the treatment of human African trypanosomiasis;Nok;Parasitol Res,2003

4. Target repurposing for neglected diseases;Pollastri;Future Med Chem,2011

5. The human Aurora kinase inhibitor danusertib is a lead compound for anti-trypanosomal drug discovery via target repurposing;Ochiana;Eur J Med Chem,2013

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