Synthesis and Antitumor Activity of Natural Compound Aloe Emodin Derivatives

Author:

Thimmegowda Naraganahalli R.12,Park Chanmi1,Shwetha Bettaswamigowda1,Sakchaisri Krisada1,Liu Kangdong13,Hwang Joonsung1,Lee Sangku1,Jeong Sook J.1,Soung Nak K.1,Jang Jae H.4,Ryoo In-Ja4,Ahn Jong S.4,Erikson Raymond L.5,Kim Bo Y.1

Affiliation:

1. World Class Institute (WCI); Incurable Diseases Research Center; Korea Research Institute of Bioscience and Biotechnology (KRIBB); Ochang, Cheongwon 363-883 Korea

2. Department of Chemistry; Govt.S K S J T Institute; Bangalore Karnataka 560001 India

3. Basic Medical College; Zhengzhou University; ZhengZhou 450001 China

4. Chemical Biology Research Center; Korea Research Institute of Bioscience and Biotechnology (KRIBB); Ochang, Cheongwon 363-883 Korea

5. Department of Molecular and Cellular Biology; Harvard University; Cambridge MA 02138 USA

Publisher

Wiley

Subject

Molecular Medicine,Biochemistry,Drug Discovery,Pharmacology,Organic Chemistry

Reference9 articles.

1. Aloe-emodin Is a new type of anticancer agent with selective activity against neuroectodermal tumors1;Pecere;Cancer Res,2000

2. The compounds in Aloe leaf exudates: a review;Reynolds;Bot J Linn Soc,1985

3. Natural anthraquinone drugs;Fairbairn;Pharmacology,1980

4. Aloe-emodin suppresses prostate cancer by targeting the mTOR complex 2;Liu;Carcinogenesis,2012

5. Aloe-emodin induces cell death through S-phase arrest and caspase-dependent pathways in human tongue squamous cancer SCC-4 cells;Chiu;Anticancer Res,2009

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