Synthesis and Bio-Evaluation of New18F-Labeled Pyridaben Analogs with Improved Stability for Myocardial Perfusion Imaging in Mice

Author:

Mou Tiantian12,Zhao Zuoquan34,Zhang Pu23,Fang Wei4,Peng Cheng5,Lu Jie2,Wang Qian1,Ma Yunchuan5,Zhang Xianzhong3

Affiliation:

1. Department of Nuclear Medicine; Beijing Anzhen Hospital; Capital Medical University; Beijing 100029 China

2. Key Laboratory of Radiopharmaceuticals; Ministry of Education; College of Chemistry; Beijing Normal University; Beijing 100875 China

3. Center for Molecular Imaging and Translational Medicine; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics; School of Public Health; Xiamen University; Xiamen 361102 China

4. Department of Nuclear Medicine; Cardiovascular Institute and Fuwai Hospital; Chinese Academy of Medical Sciences; Beijing 100037 China

5. Beijing PET Center of Xuanwu Hospital; Capital Medical University; Beijing 100053 China

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

Molecular Medicine,Biochemistry,Drug Discovery,Pharmacology,Organic Chemistry

Reference21 articles.

1. Nuclear cardiology: present and future;Russell;Curr Probl Cardiol,2006

2. Characterization of uptake of the new PET imaging compound 18F-fluorobenzyl triphenyl phosphonium in dog myocardium;Madar;J Nucl Med,2006

3. Synthesis of fluorine-18 labeled rhodamine B: a potential PET myocardial perfusion imaging agent;Heinrich;Appl Radiat Isot,2010

4. Assessment of 18F-labeled mitochondrial complex I inhibitors as PET myocardial perfusion imaging agents in rats, rabbits, and primates;Yu;Eur J Nucl Med Mol Imaging,2009

5. Mechanism of uptake and retention of F-18 BMS-747 158-02 in cardiomyocytes: a novel PET myocardial imaging agent;Yalamanchili;J Nucl Cardiol,2007

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