Sphingosine and FTY720 are potent inhibitors of the transient receptor potential melastatin 7 (TRPM7) channels
Author:
Affiliation:
1. Calhoun Cardiology Center; Department of Cell Biology; University of Connecticut Health Center; Farmington; CT; USA
Publisher
Wiley
Subject
Pharmacology
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1111/bph.12012/fullpdf
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2. Decreased levels of sphingosine, a natural antimicrobial agent, may be associated with vulnerability of the stratum corneum from patients with atopic dermatitis to colonization by Staphylococcus aureus;Arikawa;J Invest Dermatol,2002
3. Selective cancer cell apoptosis induced by FTY720; evidence for a Bcl-dependent pathway and impairment in ERK activity;Azuma;Anticancer Res,2003a
4. Induction of apoptosis in human bladder cancer cells in vitro and in vivo caused by FTY720 treatment;Azuma;J Urol,2003b
5. The immune modulator FTY720 inhibits sphingosine-1-phosphate lyase activity;Bandhuvula;J Biol Chem,2005
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