Induction of Apoptosis in Human Bladder Cancer Cells In Vitro and In Vivo Caused by FTY720 Treatment

Author:

AZUMA HARUHITO1,TAKAHARA SHIRO1,HORIE SHIGEO1,MUTO SATORU1,OTSUKI YOSHINORI1,KATSUOKA YOJI1

Affiliation:

1. From the Departments of Urology, Anatomy and Biology, Osaka Medical College, Takatsuki and Departments of Urology, Osaka University Graduate School of Medicine, Suita, Osaka, Kyorin University Medical School, Mitaka and Tokyo University Graduate School of Medicine, Bunkyou-ku, Tokyo, Japan

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Urology

Reference15 articles.

1. A novel immunosuppressant, FTY720, with a unique mechanism of action, induces long-term graft acceptance in rat and dog allotransplantation;Suzuki;Transplantation,1996

2. Induction of selective cell death targeting on mature T-lymphocytes in rats by a novel immunosuppressant, FTY720;Enosawa;Immunopharmacology,1996

3. Marked prevention of tumor growth and metastasis by a novel immunosuppressive agent, FTY720, in mouse breast cancer models;Azuma;Cancer Res,2002

4. Differential activation of c-Jun NH2-terminal kinase and p38 pathways during FTY720-induced apoptosis of T lymphocytes that is suppressed by the extracellular signal-regulated kinase pathway;Matsuda;J Immunol,1999

5. Anticarcinogenic effect of FTY720 in human prostate carcinoma DU145 cells: modulation of mitogenic signaling, FAK, cell-cycle entry and apoptosis;Permpongkosol;Int J Cancer,2002

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