Combined Anti-CD154/CTLA4Ig Costimulation Blockade-Based Therapy Induces Donor-Specific Tolerance to Vascularized Osteomyocutaneous Allografts

Author:

Lin C. H.1,Wang Y. L.1,Anggelia M. R.1,Chuang W. Y.2,Cheng H. Y.1,Mao Q.3,Zelken J. A.1,Lin C. H.1,Zheng X. X.4,Lee W. P. A.3,Brandacher G.3

Affiliation:

1. Center for Vascularized Composite Allotransplantation; Department of Plastic and Reconstructive Surgery; Chang Gung Memorial Hospital, and School of Medicine; Chang Gung University; Taoyuan Taiwan

2. Department of Pathology; Chang Gung Memorial Hospital; Chang Gung Medical College and Chang Gung University; Taoyuan Taiwan

3. Department of Plastic and Reconstructive Surgery; Vascularized Composite Allotransplantation (VCA) Laboratory; Johns Hopkins University School of Medicine; Baltimore MD

4. Research Center of Translational Medicine; Shanghai East Hospital; Tongji University; Shanghai China

Funder

Ministry of Science and Technology of Taiwan

Chang Gung Medical Foundation

Publisher

Wiley

Subject

Pharmacology (medical),Transplantation,Immunology and Allergy

Reference55 articles.

1. Composite tissue allotransplantation and reconstructive surgery: First clinical applications;Petit;Ann Surg,2003

2. Immunosuppressive strategies in transplantation;Denton;Lancet,1999

3. Acute graft-versus-host reaction can be aborted by blockade of costimulatory molecules;Hakim;J Immunol,1995

4. CD28-B7 T cell costimulatory blockade by CTLA4Ig in the rat renal allograft model: Inhibition of cell-mediated and humoral immune responses in vivo;Akalin;Transplantation,1996

5. CD28-B7 T cell costimulatory blockade by CTLA4Ig in sensitized rat recipients: Induction of transplantation tolerance in association with depressed cell-mediated and humoral immune responses;Onodera;J Immunol,1997

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