State of the art: Intrapartum antibiotics in cesarean section, the infant microbiota and allergic diseases

Author:

Moore Jassy1,Navarro Severine23,McCarthy Kate14,Rashid Ridwan B.2,Phipps Simon2,Amoako Akwasi15ORCID,Callaway Leonie16,Eley Victoria17ORCID

Affiliation:

1. Faculty of Medicine The University of Queensland Herston Queensland Australia

2. QIMR Berghofer Institute of Medical Research Herston Queensland Australia

3. Center for Childhood Nutrition Research, Faculty of Health Queensland University of Technology Brisbane Queensland Australia

4. Department of Infectious Disease The Royal Brisbane and Women's Hospital Herston Queensland Australia

5. Department of Obstetrics and Gynecology The Royal Brisbane and Women's Hospital Herston Queensland Australia

6. Women's and Newborns Services The Royal Brisbane and Women's Hospital Herston Queensland Australia

7. Department of Anesthesia and Perioperative Medicine The Royal Brisbane and Women's Hospital Herston Queensland Australia

Abstract

AbstractWith increasing rates of cesarean section worldwide and international guidelines advising pre‐incision antibiotics, neonatal exposure to pre‐birth antibiotics is higher than ever before. Emerging evidence has raised concern regarding the impact of such antibiotics on the neonatal intestinal microbiota, immune system development and health conditions later in life. This narrative review investigates current protocols for intrapartum prophylactic antibiotics in cesarean section, how this and other factors may affect the neonatal intestinal microbiota and whether intrapartum antibiotics used for cesarean section are linked to the development of allergic disease.

Funder

Children's Hospital Foundation

Publisher

Wiley

Subject

Obstetrics and Gynecology,General Medicine

Reference109 articles.

1. Global, regional, and national sepsis incidence and mortality, 1990–2017: analysis for the Global Burden of Disease Study

2. Prophylactic antibiotics before cord clamping in cesarean delivery: a systematic review

3. Timing of intravenous prophylactic antibiotics for preventing postpartum infectious morbidity in women undergoing cesarean delivery;Mackeen AD;Cochrane Database Syst Rev,2014

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