Translational engagement of lysophosphatidic acid receptor 1 in skin fibrosis: from dermal fibroblasts of patients with scleroderma to tight skin 1 mouse

Author:

Ledein Laetitia1ORCID,Léger Bertrand1,Dees Clara2ORCID,Beyer Christian2ORCID,Distler Alfiya2,Vettori Serena3ORCID,Boukaiba Rachid4,Bidouard Jean Pierre1ORCID,Schaefer Matthias5,Pernerstorfer Josef5,Ruetten Hartmut5,Jagerschmidt Alexandre1,Janiak Philip1ORCID,Distler Jörg H.W.2ORCID,Distler Oliver6ORCID,Illiano Stéphane1ORCID

Affiliation:

1. Cardiovascular & Metabolism Unit Sanofi Chilly‐Mazarin France

2. Department of Internal Medicine 3, Institute for Clinical Immunology University of Erlangen‐Nuremberg Erlangen Germany

3. Department of Clinical and Experimental Medicine, Rheumatology Unit Second University of Naples Naples Italy

4. IDD Department Sanofi Vitry‐sur‐Seine France

5. R&D Diabetes Division Sanofi Frankfurt Germany

6. Department of Rheumatology University Hospital Zurich Zürich Switzerland

Funder

Roche

Pfizer

Merck Sharp and Dohme

Mitsubishi Tanabe Pharma Corporation

Medac

Eli Lilly and Company

Italfarmaco

CSL Behring

Amgen

Acceleron

Actelion Pharmaceuticals

AbbVie

UCB

Novartis

GlaxoSmithKline

Celgene

Boehringer Ingelheim

Bayer

Bristol-Myers Squibb

aTyr

Array BioPharma

Sanofi

Publisher

Wiley

Subject

Pharmacology

Reference38 articles.

1. Overview of pathogenesis of systemic sclerosis;Abraham D. J.;Rheumatology (Oxford),2009

2. Activation of canonical Wnt signalling is required for TGF-β-mediated fibrosis

3. Goals and practicalities of immunoblotting and immunohistochemistry: A guide for submission to the British Journal of Pharmacology

4. The Concise Guide to PHARMACOLOGY 2019/20: G protein‐coupled receptors;Alexander S. P. H.;British Journal of Pharmacology,2019

5. Lysophosphatidic Acid Receptor 1 Antagonist SAR100842 for Patients With Diffuse Cutaneous Systemic Sclerosis

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