Body weight, gender and pregnancy affect enantiomer-specific ketorolac pharmacokinetics

Author:

Välitalo Pyry A.1,Kemppainen Heidi12,Kulo Aida3,Smits Anne4,van Calsteren Kristel56,Olkkola Klaus T.7,de Hoon Jan89,Knibbe Catherijne A. J.110,Allegaert Karel611

Affiliation:

1. Division of Pharmacology, Leiden Academic Centre for Drug Research; Leiden University; Leiden the Netherlands

2. School of Pharmacy; University of Eastern Finland; Kuopio Finland

3. Institute of Pharmacology, Clinical Pharmacology and Toxicology, Faculty of Medicine; University of Sarajevo; Sarajevo Bosnia and Herzegovina

4. Neonatal Intensive Care Unit; University Hospitals Leuven; Leuven Belgium

5. Department of Obstetrics and Gynecology; University Hospitals Leuven; Leuven Belgium

6. Department of Development and Regeneration; University Hospitals Leuven; Leuven Belgium

7. Department of Anaesthesiology, Intensive Care and Pain Medicine; University of Helsinki and Helsinki University Hospital; Helsinki Finland

8. Department of Pharmaceutical and Pharmacological Sciences; KU Leuven; Belgium

9. Center for Clinical Pharmacology; University Hospitals Leuven; Leuven Belgium

10. Department of Clinical Pharmacy; St Antonius Hospital; Nieuwegein the Netherlands

11. Department of Pediatric Surgery and Intensive Care; Erasmus MC-Sophia Children's Hospital; Rotterdam the Netherlands

Funder

Dutch Organization for Scientific Research

Belgian Society for Anesthesia and Resuscitation

Partnership for Advanced Computing in Europe AISBL

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference35 articles.

1. The IUPHAR/BPS guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands;Southan;Nucleic Acids Res,2016

2. The concise guide to PHARMACOLOGY 2015/16: Enzymes;Alexander;Br J Pharmacol,2015

3. Ketorolac tromethamine pharmacokinetics and metabolism after intravenous, intramuscular, and oral administration in humans and animals;Mroszczak;Pharmacotherapy,1990

4. Clinical pharmacokinetics of ketorolac tromethamine;Brocks;Clin Pharmacokinet,1992

5. Ketorolac tromethamine absorption, distribution, metabolism, excretion, and pharmacokinetics in animals and humans;Mroszczak;Drug Metab Dispos Biol Fate Chem,1987

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