Impact of enantiomer‐specific changes in pharmacokinetics between infants and adults on the target concentration of racemic ketorolac: A pooled analysis

Author:

Cloesmeijer Michael E.12ORCID,Esdonk Michiel J.13,Lynn Anne M.4,Smits Anne56,Tibboel Dick7,Daali Youssef8,Olkkola Klaus T.9,Allegaert Karel61011,Mian Paola712ORCID

Affiliation:

1. Systems Biomedicine and Pharmacology, Leiden Academic Centre for Drug Research Leiden University Leiden The Netherlands

2. Department of Hospital Pharmacy ‐ Clinical Pharmacology Amsterdam University Medical Centres Amsterdam The Netherlands

3. Centre for Human Drug Research Leiden The Netherlands

4. Department of Anesthesiology & Pain Medicine, Seattle Children's Hospital University of Washington School of Medicine Seattle WA USA

5. Neonatal Intensive Care Unit University Hospitals Leuven Leuven Belgium

6. Department of Development and Regeneration, KU Leuven Leuven Belgium

7. Intensive Care and Department of Paediatric Surgery, Erasmus MC Sophia Children's Hospital Rotterdam The Netherlands

8. Division of Clinical Pharmacology and Toxicology Geneva University Hospitals Geneva Switzerland

9. Department of Anaesthesiology, Intensive Care and Pain Medicine University of Helsinki and Helsinki University Hospital Helsinki Finland

10. Pharmaceutical and Pharmacological Sciences, KU Leuven Leuven Belgium

11. Clinical Pharmacy, Erasmus MC Rotterdam Rotterdam the Netherlands

12. Department of Clinical Pharmacy, Medisch Spectrum Twente Enschede the Netherlands

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

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