Tenapanor administration and the activity of the H+-coupled transporter PepT1 in healthy volunteers

Author:

Johansson Susanne1,Rosenbaum David P.2ORCID,Palm Johan3,Stefansson Bergur4,Knutsson Mikael5,Lisbon Eleanor A.6,Hilgendorf Constanze7

Affiliation:

1. Quantitative Clinical Pharmacology, Innovative Medicines and Early Development Biotech Unit; AstraZeneca; Mölndal Sweden

2. Ardelyx Inc.; Fremont CA USA

3. Product Development, Pharmaceutical Technology & Development, Operations; AstraZeneca; Mölndal Sweden

4. Cardiovascular Metabolic Diseases, Global Medicines Development; AstraZeneca; Mölndal Sweden

5. Biometrics & Information Sciences, Global Medicines Development; AstraZeneca; Mölndal Sweden

6. QuintilesIMS; Overland Park KS USA

7. Drug Metabolism and Pharmacokinetics, Cardiovascular and Metabolic Diseases, Innovative Medicines and Early Development Biotech Unit; AstraZeneca; Mölndal Sweden

Funder

AstraZeneca

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference36 articles.

1. The IUPHAR/BPS guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands;Southan;Nucl Acids Res,2016

2. The Concise guide to PHARMACOLOGY 2015/16: Transporters;Alexander;Br J Pharmacol,2015

3. Intestinal inhibition of the Na+/H+ exchanger 3 prevents cardiorenal damage in rats and inhibits Na+ uptake in humans;Spencer;Sci Transl Med,2014

4. Renal and intestinal absorptive defects in mice lacking the NHE3 Na+/H+ exchanger;Schultheis;Nat Genet,1998

5. Cloning and sequencing of a rabbit cDNA encoding an intestinal and kidney-specific Na+/H+ exchanger isoform (NHE-3);Tse;J Biol Chem,1992

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