AnAANAT/ASMTtransgenic animal model constructed with CRISPR/Cas9 system serving as the mammary gland bioreactor to produce melatonin-enriched milk in sheep

Author:

Ma Teng1,Tao Jingli1,Yang Minghui1,He Changjiu1,Tian Xiuzhi1,Zhang Xiaosheng2,Zhang Jinlong2,Deng Shoulong3,Feng Jianzhong2,Zhang Zhenzhen1,Wang Jing1,Ji Pengyun1,Song Yukun1,He Pingli4,Han Hongbing1,Fu Juncai1,Lian Zhengxing1,Liu Guoshi1ORCID

Affiliation:

1. National Engineering Laboratory for Animal Breeding; Key Laboratory of Animal Genetics and Breeding of the Ministry of Agriculture; Beijing Key Laboratory for Animal Genetic Improvement; College of Animal Science and Technology; China Agricultural University; Beijing China

2. Institute of Animal Husbandry and Veterinary; Academy of Agricultural Sciences of Tianjin; Tianjin China

3. State Key Laboratory of Stem Cell and Reproductive Biology; Institute of Zoology; Chinese Academy of Sciences; Beijing China

4. State Key Laboratory of Animal Nutrition; College of Animal Science and Technology; China Agricultural University; Beijing China

Funder

Genetically Modified Organisms Breeding Major Projects of China

National Natural Science Foundation of China

Xinjiang Technology Support Program

Cooperation Fund of China Agricultural University and Xinjiang Agricultural University

Publisher

Wiley

Subject

Endocrinology

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