Expert consensus on the diagnosis and treatment of NTRK gene fusion solid tumors in China

Author:

Xu Chunwei12ORCID,Si Lu3,Wang Wenxian4ORCID,Li Ziming5,Song Zhengbo4ORCID,Wang Qian6,Liu Aijun7,Yu Jinpu8,Fang Wenfeng9,Zhong Wenzhao10ORCID,Wang Zhijie11,Zhang Yongchang12ORCID,Liu Jingjing13,Zhang Shirong14ORCID,Cai Xiuyu15,Liu Anwen16,Li Wen17,Zhan Ping2,Liu Hongbing2ORCID,Lv Tangfeng2,Miao Liyun18ORCID,Min Lingfeng19,Chen Yu20,Yuan Jingping21,Wang Feng22,Jiang Zhansheng23ORCID,Lin Gen20ORCID,Pu Xingxiang24,Lin Rongbo20,Liu Weifeng25,Rao Chuangzhou26,Lv Dongqing27,Yu Zongyang28,Lei Lei4,Li Xiaoyan29,Tang Chuanhao30,Zhou Chengzhi31ORCID,Zhang Junping32,Xue Junli33,Guo Hui34,Chu Qian35,Meng Rui36,Wu Jingxun37,Zhang Rui38,Hu Xiao39,Zhou Jin40,Zhu Zhengfei41ORCID,Li Yongheng42,Qiu Hong35,Xia Fan41,Lu Yuanyuan43,Chen Xiaofeng44,Ge Rui45,Dai Enyong46,Han Yu47,Pan Weiwei48,Luo Jiancheng49,Jia Hongtao49,Dong Xiaowei50,Pang Fei50,Wang Kai50,Wang Liping51,Zhu Youcai52,Xie Yanru53,Lin Xinqin31ORCID,Cai Jing16ORCID,Wei Jia54,Lan Fen17,Feng Huijing32,Wang Lin55,Du Yingying56ORCID,Yao Wang57,Shi Xuefei58,Niu Xiaomin5,Yuan Dongmei2,Yao Yanwen2,Huang Jianhui53,Zhang Yinbin59,Sun Pingli60,Wang Hong61,Ye Mingxiang2,Wang Dong2,Wang Zhaofeng2,Wan Bing62,Lv Donglai63ORCID,Wei Qing4,Kang Jin10,Zhang Jiatao10,Zhang Chao11,Yu Genhua64,Ou Juanjuan65,Shi Lin66,Li Zhongwu67,Liu Zhefeng61,Liu Jing68,Yang Nong12,Wu Lin24,Wang Huijuan69,Jin Gu70,Yang Liu71,Wang Guansong72,Fang Meiyu4,Fang Yong73,Li Yuan74,Wang Xiaojia4,Zhang Yiping4,Ma Shenglin75,Wang Biyun76,Zhang Xiaotian77,Song Yong2ORCID,Lu Yuanzhi78ORCID

Affiliation:

1. Institute of Cancer and Basic Medicine (ICBM) Chinese Academy of Sciences Hangzhou People's Republic of China

2. Department of Respiratory Medicine, Affiliated Jinling Hospital Medical School of Nanjing University Nanjing People's Republic of China

3. Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Melanoma and Sarcoma Peking University Cancer Hospital and Institute Beijing People's Republic of China

4. Department of Chemotherapy Chinese Academy of Sciences University Cancer Hospital (Zhejiang Cancer Hospital) Hangzhou People's Republic of China

5. Department of Shanghai Lung Cancer Center, Shanghai Chest Hospital Shanghai Jiao Tong University Shanghai People's Republic of China

6. Department of Respiratory Medicine Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine Nanjing People's Republic of China

7. Senior Department of Pathology The 7th Medical Center of PLA General Hospital Beijing People's Republic of China

8. Cancer Molecular Diagnostics Core Tianjin Medical University Cancer Institute and Hospital Tianjin People's Republic of China

9. Department of Medical Oncology Sun Yat‐sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine Guangzhou People's Republic of China

10. Guangdong Lung Cancer Institute, Guangdong Provincial Laboratory of Translational Medicine in Lung Cancer Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, School of Medicine Guangzhou People's Republic of China

11. State Key Laboratory of Molecular Oncology, Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing People's Republic of China

12. Department of Medical Oncology, Lung Cancer and Gastrointestinal Unit Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University Changsha People's Republic of China

13. Department of Thoracic Cancer Jilin Cancer Hospital Changchun People's Republic of China

14. Translational Medicine Research Center, Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Affiliated Hangzhou First People's Hospital, Cancer Center Zhejiang University School of Medicine Hangzhou People's Republic of China

15. Department of VIP Inpatient Sun Yet‐Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine Guangzhou People's Republic of China

16. Department of Oncology Second Affiliated Hospital of Nanchang University Nanchang People's Republic of China

17. Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine Second Affiliated Hospital of Zhejiang University School of Medicine, Cancer Center, Zhejiang University Hangzhou People's Republic of China

18. Department of Respiratory Medicine Affiliated Drum Tower Hospital, Medical School of Nanjing University Nanjing People's Republic of China

19. Department of Respiratory Medicine Clinical Medical School of Yangzhou University, Subei People's Hospital of Jiangsu Province Yangzhou People's Republic of China

20. Department of Medical Oncology Fujian Medical University Cancer Hospital and Fujian Cancer Hospital Fuzhou People's Republic of China

21. Department of Pathology Renmin Hospital of Wuhan University Wuhan People's Republic of China

22. Department of Internal Medicine, Cancer Center of PLA, Qinhuai Medical Area Affiliated Jinling Hospital, Medical School of Nanjing University Nanjing People's Republic of China

23. Department of Integrative Oncology Tianjin Medical University Cancer Institute and Hospital Tianjin People's Republic of China

24. Department of Medical Oncology, Lung Cancer and Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine Central South University Changsha People's Republic of China

25. Department of Orthopaedic Oncology Surgery, Beijing Ji Shui Tan Hospital Peking University Beijing People's Republic of China

26. Department of Radiotherapy and Chemotherapy, Hwamei Hospital University of Chinese Academy of Sciences Ningbo People's Republic of China

27. Department of Pulmonary Medicine Taizhou Hospital of Wenzhou Medical University Taizhou People's Republic of China

28. Department of Respiratory Medicine, The 900th Hospital of the Joint Logistics Team (The Former Fuzhou General Hospital) Fujian Medical University Fuzhou People's Republic of China

29. Department of Oncology, Beijing Tiantan Hospital Capital Medical University Beijing People's Republic of China

30. Department of Medical Oncology Peking University International Hospital Beijing People's Republic of China

31. State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health The First Affiliated Hospital of Guangzhou Medical University (The First Affiliated Hospital of Guangzhou Medical University) Guangzhou People's Republic of China

32. Department of Thoracic Oncology Shanxi Academy of Medical Sciences, Shanxi Bethune Hospital Taiyuan People's Republic of China

33. Department of Oncology, Shanghai East Hospital, School of Medicine Tongji University Shanghai People's Republic of China

34. Department of Medical Oncology The First Affiliated Hospital of Xi'an Jiaotong University Xi'an People's Republic of China

35. Department of Oncology, Tongji Hospital of Tongji Medical College Huazhong University of Science and Technology Wuhan People's Republic of China

36. Cancer Center, Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan People's Republic of China

37. Department of Medical Oncology, The First Affiliated Hospital of Medicine Xiamen University Xiamen People's Republic of China

38. Department of Medical Oncology Cancer Hospital of China Medical University Shenyang People's Republic of China

39. Zhejiang Key Laboratory of Radiation Oncology Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital) Hangzhou People's Republic of China

40. Department of Medical Oncology, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, School of Medicine University of Electronic Science and Technology Chengdu People's Republic of China

41. Department of Radiation Oncology Fudan University Shanghai Cancer Center Shanghai People's Republic of China

42. Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Radiation Oncology Peking University Cancer Hospital and Institute Beijing People's Republic of China

43. State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases Fourth Military Medical University Xi'an People's Republic of China

44. Department of Oncology Jiangsu Province Hospital and Nanjing Medical University First Affiliated Hospital Nanjing People's Republic of China

45. Department of General Surgery Huadong Hospital Affiliated to Fudan University Shanghai People's Republic of China

46. Department of Oncology and Hematology China‐Japan Union Hospital of Jilin University Changchun People's Republic of China

47. Department of Gastrointestinal Oncology Harbin Medical University Cancer Hospital Harbin People's Republic of China

48. Department of Cell Biology, College of Medicine Jiaxing University Jiaxing People's Republic of China

49. Aiyi Technology Co., Ltd Beijing People's Republic of China

50. Department of Pathology Shanghai OrigiMed Co, Ltd Shanghai People's Republic of China

51. Department of Oncology Baotou Cancer Hospital Baotou People's Republic of China

52. Department of Thoracic Disease Diagnosis and Treatment Center, Zhejiang Rongjun Hospital The Third Affiliated Hospital of Jiaxing University Jiaxing People's Republic of China

53. Department of Oncology Lishui Municipal Central Hospital Lishui People's Republic of China

54. Department of the Comprehensive Cancer Center Affiliated Drum Tower Hospital, Medical School of Nanjing University Nanjing People's Republic of China

55. Department of Pathology Shanxi Academy of Medical Sciences, Shanxi Bethune Hospital Taiyuan People's Republic of China

56. Department of Oncology The First Affiliated Hospital of Anhui Medical University Hefei People's Republic of China

57. Department of Interventional Oncology The First Affiliated Hospital, Sun Yat‐sen University Guangzhou People's Republic of China

58. Department of Respiratory Medicine, Huzhou Hospital Zhejiang University School of Medicine Huzhou People's Republic of China

59. Department of Oncology, The Second Affiliated Hospital of Medical College Xi'an Jiaotong University Xi'an People's Republic of China

60. Department of Pathology The Second Hospital of Jilin University Changchun People's Republic of China

61. Senior Department of Oncology The 5th Medical Center of PLA General Hospital Beijing People's Republic of China

62. Department of Respiratory Medicine The Affiliated Jiangning Hospital of Nanjing Medical University Nanjing People's Republic of China

63. Department of Clinical Oncology The 901 Hospital of Joint Logistics Support Force of People Liberation Army Hefei People's Republic of China

64. Department of Radiation Oncology Zhebei Mingzhou Hospital Huzhou People's Republic of China

65. Department of Oncology and Southwest Cancer Center, Southwest Hospital Third Military Medical University (Army Medical University) Chongqing People's Republic of China

66. Department of Respiratory Medicine Zhongshan Hospital, Fudan University Shanghai People's Republic of China

67. Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Pathology Peking University Cancer Hospital and Institute Beijing People's Republic of China

68. Department of Oncology, Ruijin Hospital Shanghai Jiao tong University School of Medicine Shanghai People's Republic of China

69. Department of Internal Medicine The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital Zhengzhou People's Republic of China

70. Department of Bone and Soft‐Tissue Surgery Chinese Academy of Sciences University Cancer Hospital (Zhejiang Cancer Hospital) Hangzhou People's Republic of China

71. Key Laboratory of Tumor Molecular Diagnosis and Individualized Medicine of Zhejiang Province Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College Hangzhou People's Republic of China

72. Institute of Respiratory Diseases, Xinqiao Hospital Third Military Medical University Chongqing People's Republic of China

73. Department of Medical Oncology, Sir Run Run Shaw Hospital Zhejiang University Hangzhou People's Republic of China

74. Department of Pathology Fudan University Shanghai Cancer Center Shanghai People's Republic of China

75. Department of Oncology, Key Laboratory of Clinical Cancer Pharmacology and Toxicology, Research of Zhejiang Province Affiliated Hangzhou Cancer Hospital, Cancer Center, Zhejiang University School of Medicine Hangzhou People's Republic of China

76. Department of Breast Cancer and Urological Medical Oncology Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan Unviersity Shanghai People's Republic of China

77. Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Gastrointestinal Oncology Peking University Cancer Hospital and Institute Beijing People's Republic of China

78. Department of Clinical Pathology The First Affiliated Hospital of Jinan University Guangzhou People's Republic of China

Publisher

Wiley

Subject

Pulmonary and Respiratory Medicine,Oncology,General Medicine

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