Targeting TRK family proteins in cancer

Author:

Khotskaya Yekaterina B.,Holla Vijaykumar R.,Farago Anna F.,Mills Shaw Kenna R.,Meric-Bernstam Funda,Hong David S.

Funder

The Cancer Prevention and Research Institute of Texas

Sheikh Khalifa Bin Zayed Al Nahyan Institute for Personalized Cancer Therapy

MD Anderson Cancer Center Support Grant

NCATS

Publisher

Elsevier BV

Subject

Pharmacology (medical),Pharmacology

Reference97 articles.

1. SNS-314, a pan-Aurora kinase inhibitor, shows potent anti-tumor activity and dosing flexibility in vivo;Arbitrario;Cancer Chemotherapy and Pharmacology,2010

2. The TPM3-NTRK1 rearrangement is a recurring event in colorectal carcinoma and is associated with tumor sensitivity to TRKA kinase inhibition;Ardini;Molecular Oncology,2014

3. Neurotrophin signaling: Many exciting surprises!;Arevalo;Cellular and Molecular Life Sciences,2006

4. TrkA immunoglobulin-like ligand binding domains inhibit spontaneous activation of the receptor;Arevalo;Molecular and Cellular Biology,2000

5. Phase (Ph) 1/2a study of TSR-011, a potent inhibitor of ALK and TRK, in advanced solid tumors including crizotinib-resistant ALK positive non-small cell lung cancer;Arkenau;Journal of Clinical Oncology,2015

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