Crystal structure of Thermoanaerobacter tengcongensis hypoxanthine-guanine phosphoribosyl transferase L160I mutant − insights into inhibitor design

Author:

Chen Qiang,You Delin,Liang Yuhe,Su Xiaodong,Gu Xiaocheng,Luo Ming,Zheng Xiaofeng

Publisher

Wiley

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference18 articles.

1. Parasite enzymes as potential targets for antiparasitic chemotherapy;Wang;J Med Chem,1984

2. Hypoxanthine-guanine phosphoribosyltransferase as a therapeutic target in protozoal infections;Ullman;Infect Agents Dis,1995

3. Inhibition of utilization of hypoxanthine and guanine in cells treated with the carbocyclic analog of adenosine. Phosphates of carbocyclic nucleoside analogs as inhibitors of hypoxanthine (guanine) phosphoribosyltransferase;Bennett;Mol Pharmacol,1985

4. Purine salvage enzymes of parasites as targets for structure-based inhibitor design;Craig;Parasitol Today,1997

5. Rational design of novel antimicrobials: blocking purine salvage in a parasitic protozoan;Somoza;Biochemistry,1998

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