Cytochrome P450 promiscuity leads to a bifurcating biosynthetic pathway for tanshinones

Author:

Guo Juan1,Ma Xiaohui12,Cai Yuan13,Ma Ying1,Zhan Zhilai1,Zhou Yongjin J.3,Liu Wujun3,Guan Mengxin4,Yang Jian1,Cui Guanghong1,Kang Liping1,Yang Lei5,Shen Ye1,Tang Jinfu1,Lin Huixin1,Ma Xiaojing1,Jin Baolong1,Liu Zhenming4,Peters Reuben J.6,Zhao Zongbao K.3,Huang Luqi1

Affiliation:

1. State Key Laboratory Breeding Base of Dao‐di Herbs, National Resource Center for Chinese Materia Medica China Academy of Chinese Medical Sciences Beijing 100700 China

2. Pharmacy College Chengdu University of Traditional Chinese Medicine Chengdu 611137 China

3. Division of Biotechnology Dalian Institute of Chemical Physics CAS Dalian 116023 China

4. State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical Sciences Peking University Beijing 100191 China

5. Plant Science Research Center Shanghai Chenshan Botanical Garden Shanghai Key Laboratory of Plant Functional Genomics and Resources Shanghai 201602 China

6. Roy J. Carver Department of Biochemistry, Biophysics, and Molecular Biology Iowa State University Ames IA 50011 USA

Funder

National Natural Science Foundation of China

National Institutes of Health

National High Technology Research and Development Program

Publisher

Wiley

Subject

Plant Science,Physiology

Reference41 articles.

1. Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

2. Biochemistry of Terpenoids: Monoterpenes, Sesquiterpenes and Diterpenes

3. Cytochromes P450;Bak S;Arabidopsis Book/American Society of Plant Biologists,2011

4. Computational identification and systematic classification of novel cytochrome P450 genes in Salvia miltiorrhiza;Chen H;PLoS ONE,2014

5. Effects of Combined Elicitors on Tanshinone Metabolic Profiling and SmCPS Expression in Salvia miltiorrhiza Hairy Root Cultures

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