The impact of bottlenecks on microbial survival, adaptation, and phenotypic switching in host-pathogen interactions

Author:

Moxon Richard1,Kussell Edo23

Affiliation:

1. University of Oxford Medical Sciences Division; John Radcliffe Hospital Oxford United Kingdom

2. Department of Biology and Center for Genomics and Systems Biology; 12 Waverly Place, New York University New York 10003

3. Department of Physics; New York University; 726 Broadway New York 10003

Funder

National Institute of General Medical Sciences

Publisher

Wiley

Subject

General Agricultural and Biological Sciences,Genetics,Ecology, Evolution, Behavior and Systematics

Reference63 articles.

1. Analysis of bottlenecks in experimental models of infection;Abel;PLoS Pathog.,2015

2. Stochastic switching as a survival strategy in fluctuating environments;Acar;Nat. Genet.,2008

3. A functional perspective on phenotypic heterogeneity in microorganisms;Ackermann;Nat. Rev. Micro.,2015

4. Nonselective bottlenecks control the divergence and diversification of phase-variable bacterial populations;Aidley;mBio,2017

5. Phase variation mediates reductions in expression of surface proteins during persistent meningococcal carriage;Alamro;Infect. Immun.,2014

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