Abstract
AbstractCapacity to generate adaptive variation can evolve by natural selection. However, the idea that mutation becomes biased toward specific adaptive outcomes is controversial. Here, using experimental bacterial populations, we report the evolution of enhanced evolvability via localised hyper-mutation. Key to realisation was a lineage-level birth-death dynamic, where lineage success depended upon capacity to mutate between two phenotypic states, each optima in a cycling environment. The evolved mechanism is analogous to “contingency loci” in pathogenic bacteria, whose origin was previously unclear. Subsequent evolution showed lineages with localised hyper-mutability were more likely to acquire additional adaptive mutations. Our results provide a detailed mechanistic account of the adaptive evolution of evolvability.
Publisher
Cold Spring Harbor Laboratory
Reference61 articles.
1. Adaptive divergence in experimental populations of pseudomonas fluorescens;III. mutational origins of wrinkly spreader diversity. Genetics,2007
2. The simple sequence contingency loci of Haemophilus influenzae and Neisseria meningitidis
3. Experimental evolution of bet hedging
4. Bell, G . Selection: the mechanism of evolution. Oxford University Press, 2008.
5. Ecological scaffolding and the evolution of individuality;Nat Ecol Evol,2020
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