1. Department of Pharmacology, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
2. University Department of Pharmacology, Oxford OX1 3QT, UK
3. Department of Surgery, the Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC, USA
4. Department of Medicine and Biochemistry, the Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC, USA
5. Department of the Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC, USA