Clinical significance of antinuclear antibodies in primary immune thrombocytopenia

Author:

Moulis Guillaume12ORCID,Aladjidi Nathalie3ORCID,Godeau Bertrand4ORCID

Affiliation:

1. Department of Internal Medicine, Referral Center for Autoimmune Cytopenia in Adults Toulouse University Hospital Toulouse France

2. Clinical Investigation Center 1436, Team PEPSS Toulouse University Hospital Toulouse France

3. Pediatric Hemato‐Immunology, Referral Center for Autoimmune Cytopenia in Children, CEREVANCE, CIC1401, INSERM CICP Bordeaux University Hospital Bordeaux France

4. Internal Medicine Department, Referral Center for Autoimmune Cytopenia in Adults, Hospital Henri Mondor, University Hospital Federation TRUE InnovaTive theRapy for immUne disordErs, Assistance Publique Hôpitaux de Paris (AP‐HP) University of Paris Est Créteil Créteil France

Abstract

SummaryThere are discrepancies across guidelines about whether the dosage of antinuclear antibodies (ANAs) is of use at the diagnosis of primary immune thrombocytopenia (ITP). This review describes the current knowledge about ANA prevalence in patients with primary ITP, and their potential usefulness as biomarkers for ITP evolution, response to treatments and increased risk of subsequent development of systemic lupus and thrombosis.

Publisher

Wiley

Subject

Hematology

Reference35 articles.

1. American Society of Hematology 2019 guidelines for immune thrombocytopenia

2. Updated international consensus report on the investigation and management of primary immune thrombocytopenia

3. Expert Report on Immune Thrombocytopenia: Current Diagnostics and Treatment – Recommendations from an Expert Group from Austria, Germany, and Switzerland

4. Haute Autorité de Santé.Purpura thrombopénique immunologique de l'enfant et de l'adulte. Protocole National de Diagnosticet de Soins.2017. [cited 2023 Jul 15]; Available from:https://www.has‐sante.fr/upload/docs/application/pdf/2017‐06/dir36/pnds‐_purpura_thrombopenique_immunologique.pdf

5. International recommendations for the assessment of autoantibodies to cellular antigens referred to as anti-nuclear antibodies

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