Population pharmacokinetic–pharmacodynamic modelling in oncology: a tool for predicting clinical response

Author:

Bender Brendan C.1,Schindler Emilie1,Friberg Lena E.1

Affiliation:

1. Department of Pharmaceutical Biosciences Uppsala University Uppsala Sweden

Funder

Swedish Cancer Society and DDMoRe

European Union's Seventh Framework Programme

EFPIA

Academic and SME partners

Genentech, Inc.

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference73 articles.

1. Cancer statistics, 2012

2. Drug development in oncology: classical cytotoxics and molecularly targeted agents

3. FDA.Guidance for industry. Clinical trial endpoints for the approval of cancer drugs and biologics.2007. Available athttp://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/ucm071590.pdf(last accessed 7 November 2013).

4. Progression-Free Survival: Meaningful or Simply Measurable?

5. On the Use of Change in Tumor Size to Predict Survival in Clinical Oncology Studies: Toward a New Paradigm to Design and Evaluate Phase II Studies

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