Irreversible inhibitors of the proline racemase unveil innovative mechanism of action as antibacterial agents against Clostridioides difficile-Reference-Cited by-同舟云学术

Irreversible inhibitors of the proline racemase unveil innovative mechanism of action as antibacterial agents against Clostridioides difficile

Published:2022-01-05 Issue: Volume: Page:
ISSN:1747-0277
Container-title:Chemical Biology & Drug Design
language:en
Short-container-title:Chem Biol Drug Des

Author:

Gateau Cécile¹²,Melo Guilherme D.³,Uriac Philippe⁴,Tasseau Olivier⁴,Renault Jacques⁴,Blondel Arnaud⁵,Gouault Nicolas⁴,Barbut Frédéric¹²,Minoprio Paola³

Affiliation:

1. AP‐HP Hôpital saint Antoine National Reference Laboratory for Clostridioides Difficile Paris France

2. Université de Paris INSERM UMR‐S 1139 Paris France

3. Institut Pasteur Département Santé Globale Laboratoire des Processus Infectieux à Trypanosomatidés Paris France

4. Université de Rennes 1 – Faculté de Pharmacie ISCR UMR CNRS 6226 Equipe CORINT Rennes France

5. Institut Pasteur Département de Biologie Structurale et Chimie Unité de Bioinformatique Structurale CNRS‐UMR 3528 Paris France

Publisher

Wiley

Subject

Molecular Medicine,Biochemistry,Drug Discovery,Pharmacology,Organic Chemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/cbdd.14005

Reference28 articles.

1. Designed mono- and di-covalent inhibitors trap modeled functional motions for Trypanosoma cruzi proline racemase in crystallography

2. The Future of Purification

3. Clinical Features ofClostridium difficile–Associated Infections and Molecular Characterization of Strains: Results of a Retrospective Study, 2000-2004

4. Combined Approaches for Drug Design Points the Way to Novel Proline Racemase Inhibitor Candidates to Fight Chagas’ Disease

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