A new nucleocytoplasmic RhoGAP protein contributes to control the pathogenicity ofEntamoeba histolyticaby regulating EhRacC and EhRacD activity

Author:

Hernandez-Flores Araceli1,Almaraz-Barrera Ma de Jesus1,Lozano-Amado Daniela1,Correa-Basurto Jose2,Rojo-Dominguez Arturo3,Luna-Rivera Eva1,Schnoor Michael1,Guillen Nancy4,Hernandez-Rivas Rosaura1,Vargas Miguel1

Affiliation:

1. Department of Molecular Biomedicine; Center of Research and Advanced Studies of the I.P.N; Mexico City, D.F. Mexico

2. High School of Medicine of the I.P.N; Molecular Modeling Laboratory and Drug Design; Mexico City, D.F. Mexico

3. Cuajimalpa Unit., Department of Natural Sciences; Metropolitan Autonomous University; Mexico City, D.F. Mexico

4. Institut Pasteur; Department of Cell Biology and Infection; Paris France

Funder

CONACyT México

Publisher

Hindawi Limited

Subject

Virology,Immunology,Microbiology

Reference60 articles.

1. Entamoeba histolytica: inhibition of cellular functions by overexpression of EhGEF1, a novel Rho/Rac guanine nucleotide exchange factor;Aguilar-Rojas;Exp Parasitol,2005

2. Breakpoint cluster region gene product- related domain of n-chimaerin. Discrimination between Rac-binding and GTPase-activating residues by mutational analysis;Ahmed;J Biol Chem,1994

3. EhGEF3, a novel Dbl family member, regulates EhRacA activation during chemotaxis and capping in Entamoeba histolytica;Arias-Romero;Cell Motil Cytoskeleton,2007

4. The structure of the GTPase-activating domain from p50rhoGAP;Barrett;Nature,1997

5. Computational method for general multicenter electronic structure calculations;Batcho;Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics,2000

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