Iron-modulated virulence factors of Entamoeba histolytica-Reference-Cited by-同舟云学术

Iron-modulated virulence factors of Entamoeba histolytica

Published:2018-09 Issue:11 Volume:13 Page:1329-1341
ISSN:1746-0913
Container-title:Future Microbiology
language:en
Short-container-title:Future Microbiology

Author:

Gastelum-Martínez Aurora¹,León-Sicairos Claudia¹,Plata-Guzmán Laura¹,Soto-Castro Liliana¹,León-Sicairos Nidia²,de la Garza Mireya³

Affiliation:

1. Programa Regional del Noroeste para el Posgrado en Biotecnología de la Facultad de Ciencias Químico Biológicas. Universidad Autónoma de Sinaloa. Av. de las Américas y Josefa Ortiz (Cd. Universitaria) Culiacán 80030, Sinaloa, Mexico

2. CIASaP Facultad de Medicina. Universidad Autónoma de Sinaloa. Cedros y Sauces Frac. Fresnos. Culiacán 80246, Sinaloa, México; Departamento de Investigación, Hospital Pediátrico de Sinaloa. Boulevard Constitución S/N, Col. Jorge Almada, Culiacán 80200, Sinaloa, Mexico

3. Departamento de Biología Celular, Centro de Investigación y de Estudios Avanzados del IPN (CINVESTAV-IPN), Av. Instituto Politécnico Nacional 2508, Colonia San Pedro Zacatenco 07360, CdMx, Mexico

Abstract

Entamoeba histolytica is a human parasite that causes amoebiasis, a disease that affects the colon and liver and is prevalent worldwide. This protozoan requires a high concentration of iron to survive and reproduce. Iron modulates the expression of parasite virulence factors, including hemoglobinases, hemoglobin-binding proteins and cysteine proteases, as well as proteins related to the amoebic cytoskeleton. This review summarizes the virulence factors that are affected by iron, resulting in upregulation or downregulation of E. histolytica genes. This review also discusses the functionality of iron in the mechanisms of pathogenesis.

Publisher

Future Medicine Ltd

Subject

Microbiology (medical),Microbiology

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fmb-2018-0066

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