The Effect of CYP2D6 Drug-Drug Interactions on Hydrocodone Effectiveness
Author:
Affiliation:
1. Department of Emergency Medicine; University of Colorado; Aurora CO
2. Skaggs School of Pharmacy and Pharmaceutical Sciences; San Diego CA
3. Rocky Mountain Poison & Drug Center; Denver CO
4. Department of Pharmacology; Mayo Clinic; Rochester MN
Publisher
Wiley
Subject
Emergency Medicine,General Medicine
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1111/acem.12431/fullpdf
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2. CYP2D6 phenotype determines the metabolic conversion of hydrocodone to hydromorphone;Otton;Clin Pharmacol Ther,1993
3. CYP2D6 and CYP3A4 involvement in the primary oxidative metabolism of hydrocodone by human liver microsomes;Hutchinson;Br J Clin Pharmacol,2004
4. The role of hydromorphone and OPRM1 in postoperative pain relief with hydrocodone;Boswell;Pain Phys,2013
5. Polymorphism of human cytochrome P450 2D6 and its clinical significance: Part I;Zhou;Clin Pharmacokinet,2009
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