Population pharmacokinetic modelling to assess the impact of CYP2D6 and CYP3A metabolic phenotypes on the pharmacokinetics of tamoxifen and endoxifen-Reference-Cited by-同舟云学术

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Population pharmacokinetic modelling to assess the impact of CYP2D6 and CYP3A metabolic phenotypes on the pharmacokinetics of tamoxifen and endoxifen

Published:2014-08-21 Issue:3 Volume:78 Page:572-586
ISSN:0306-5251
Container-title:British Journal of Clinical Pharmacology
language:en
Short-container-title:Br J Clin Pharmacol

Author:

ter Heine Rob¹,Binkhorst Lisette²,de Graan Anne Joy M.²,de Bruijn Peter²,Beijnen Jos H.³⁴,Mathijssen Ron H. J.²,Huitema Alwin D. R.³

Affiliation:

1. Department of Clinical Pharmacy; Meander Medical Center; Amersfoort The Netherlands

2. Department of Medical Oncology; Erasmus MC Cancer Institute; Rotterdam The Netherlands

3. Department of Pharmacy & Pharmacology; Slotervaart Hospital; Amsterdam The Netherlands

4. Department of Pharmaceutical Sciences; Utrecht Institute for Pharmaceutical Sciences; Utrecht University; Utrecht The Netherlands

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1111/bcp.12388/fullpdf

Reference46 articles.

1. Activity levels of tamoxifen metabolites at the estrogen receptor and the impact of genetic polymorphisms of phase I and II enzymes on their concentration levels in plasma;Murdter;Clin Pharmacol Ther,2011

2. Tamoxifen and metabolites in MCF7 cells: correlation between binding to estrogen receptor and inhibition of cell growth;Coezy;Cancer Res,1982

3. Tamoxifen metabolite concentrations, CYP2D6 genotype, and breast cancer outcomes;Madlensky;Clin Pharmacol Ther,2011

4. Determination of clinically therapeutic endoxifen concentrations based on efficacy from human MCF7 breast cancer xenografts;Gong;Breast Cancer Res Treat,2013

5. Impaired tamoxifen metabolism reduces survival in familial breast cancer patients;Newman;Clin Cancer Res,2008

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1. ESR1 and p53 interactome alteration defines mechanisms of tamoxifen response in luminal breast cancer;iScience;2024-06

2. Nonlinear Mixed‐Effects Model of Z‐Endoxifen Concentrations in Tamoxifen‐Treated Patients from the CEPAM Cohort;Clinical Pharmacology & Therapeutics;2024-03-18

3. Personalizing Personalized Medicine: The Confluence of Pharmacogenomics, a Person’s Medication Experience and Ethics;Pharmacy;2023-06-15

4. Toward model-informed precision dosing for tamoxifen: A population-pharmacokinetic model with a continuous CYP2D6 activity scale;Biomedicine & Pharmacotherapy;2023-04

5. Factors Influencing Pharmacokinetics of Tamoxifen in Breast Cancer Patients: A Systematic Review of Population Pharmacokinetic Models;Biology;2022-12-28

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