Proapoptotic and immunomodulatory effects of SYK inhibitor entospletinib in combination with obinutuzumab in patients with chronic lymphocytic leukaemia-Reference-Cited by-同舟云学术

Proapoptotic and immunomodulatory effects of SYK inhibitor entospletinib in combination with obinutuzumab in patients with chronic lymphocytic leukaemia

Published:2021-07-19 Issue:2 Volume:88 Page:836-841
ISSN:0306-5251
Container-title:British Journal of Clinical Pharmacology
language:en
Short-container-title:Brit J Clinical Pharma

Author:

Lam Vi¹,Best Scott²,Kittai Adam³,Orand Kirsten¹,Spurgeon Stephen E.²,Liu Tingting¹,Danilov Alexey V.¹²^ORCID

Affiliation:

1. City of Hope Comprehensive Cancer Center Duarte CA USA

2. Knight Cancer Institute, Oregon Health & Science University Portland OR USA

3. Ohio State University Columbus OH USA

Funder

Leukemia and Lymphoma Society

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/bcp.14962

Reference21 articles.

1. Incorporating acalabrutinib, a selective next‐generation Bruton tyrosine kinase inhibitor, into clinical practice for the treatment of haematological malignancies

2. Spleen Tyrosine Kinase Is Overexpressed and Represents a Potential Therapeutic Target in Chronic Lymphocytic Leukemia

3. Inhibition of constitutive and BCR-induced Syk activation downregulates Mcl-1 and induces apoptosis in chronic lymphocytic leukemia B cells

4. Selective, novel spleen tyrosine kinase (Syk) inhibitors suppress chronic lymphocytic leukemia B-cell activation and migration

5. SYK inhibition thwarts the BAFF - B-cell receptor crosstalk and thereby antagonizes Mcl-1 in chronic lymphocytic leukemia

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