The dual orexin receptor antagonist daridorexant does not affect the pharmacokinetics of the BCRP substrate rosuvastatin
Author:
Affiliation:
1. Department of Clinical Pharmacology Idorsia Pharmaceuticals Ltd Allschwil Switzerland
2. CEPHA s.r.o. Komenskeho 19 Pilsen Czech Republic
Publisher
Wiley
Subject
Physiology (medical),Pharmacology,Physiology
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1111/1440-1681.13370
Reference19 articles.
1. Orexins and Orexin Receptors: A Family of Hypothalamic Neuropeptides and G Protein-Coupled Receptors that Regulate Feeding Behavior
2. The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness
3. Accelerated Development of the Dual Orexin Receptor Antagonist ACT-541468: Integration of a Microtracer in a First-in-Human Study
4. Daridorexant, a New Dual Orexin Receptor Antagonist to Treat Insomnia Disorder
5. The Use of Physiology-Based Pharmacokinetic and Pharmacodynamic Modeling in the Discovery of the Dual Orexin Receptor Antagonist ACT-541468
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2. Effect of Daridorexant on the Pharmacokinetics of P-Glycoprotein Substrate Dabigatran Etexilate and Breast Cancer Resistance Protein Substrate Rosuvastatin in Healthy Subjects;Clinical Drug Investigation;2023-10-19
3. Daridorexant, an Orexin Receptor Antagonist for the Management of Insomnia;American Journal of Therapeutics;2023-07
4. Daridorexant: Comprehensive Review of A New Oral Agent for the Treatment of Insomnia;Annals of Pharmacotherapy;2023-01-05
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