Accelerated Development of the Dual Orexin Receptor Antagonist ACT-541468: Integration of a Microtracer in a First-in-Human Study
Author:
Affiliation:
1. Department of Clinical Pharmacology; Idorsia Pharmaceuticals Ltd; Allschwil Switzerland
2. Centre for Human Drug Research (CHDR); Leiden The Netherlands
3. Xceleron (a Pharmaron Company); Germantown Maryland USA
Funder
Idorsia Pharmaceuticals Ltd.
Publisher
Wiley
Subject
Pharmacology (medical),Pharmacology
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1002/cpt.1046/fullpdf
Reference37 articles.
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3. The hypocretin/orexin ligand-receptor system: implications for sleep and sleep disorders;Kilduff;Trends Neurosci,2000
4. Orexin/hypocretin: a neuropeptide at the interface of sleep, energy homeostasis, and reward system;Tsujino;Pharmacol. Rev.,2009
5. Motivational activation: a unifying hypothesis of orexin/hypocretin function;Mahler;Nat. Neurosci.,2014
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