Novel small molecule inhibition of IKK/NF‐κB activation reduces markers of senescence and improves healthspan in mouse models of aging-Reference-Cited by-同舟云学术

Novel small molecule inhibition of IKK/NF‐κB activation reduces markers of senescence and improves healthspan in mouse models of aging

Published:2021-11-03 Issue:12 Volume:20 Page:
ISSN:1474-9718
Container-title:Aging Cell
language:en
Short-container-title:Aging Cell

Author:

Zhang Lei¹,Zhao Jing²,Mu Xiaodong³⁴^ORCID,McGowan Sara J.¹,Angelini Luise¹,O'Kelly Ryan D.¹,Yousefzadeh Matthew J.¹,Sakamoto Ayumi⁵,Aversa Zaira⁵,LeBrasseur Nathan K.⁵^ORCID,Suh Yousin⁶,Huard Johnny³,Kamenecka Theodore M.²,Niedernhofer Laura J.¹^ORCID,Robbins Paul D.¹^ORCID

Affiliation:

1. Department of Biochemistry, Molecular Biology and Biophysics Institute on the Biology of Aging and Metabolism University of Minnesota Minneapolis Minnesota USA

2. Department of Molecular Medicine Scripps Research Jupiter Florida USA

3. Center for Regenerative Sports Medicine Steadman Philippon Research Institute Vail Colorado USA

4. Shandong First Medical University (Shandong Academy of Medical Sciences) Jinan China

5. Department of Physical Medicine and Rehabilitation and Robert and Arlene Kogod Center on Aging Rochester Minnesota USA

6. Department of Genetics and Development Columbia University New York New York USA

Funder

Foundation for the National Institutes of Health

Glenn Foundation for Medical Research

Publisher

Wiley

Subject

Cell Biology,Aging

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/acel.13486

Reference46 articles.

1. A complex secretory program orchestrated by the inflammasome controls paracrine senescence

2. Motif module map reveals enforcement of aging by continual NF-κB activity

3. Role of nuclear factor-κ B in melanoma

4. NF-κB, Inflammation, and Metabolic Disease

5. NF-κB pathway activators as potential ageing biomarkers: targets for new therapeutic strategies

Cited by 35 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Integrating Machine Learning with Multi-Omics Technologies in Geroscience: Towards Personalized Medicine;Journal of Personalized Medicine;2024-08-31

2. Ameliorative effects of mesenchymal stromal cells on senescence associated phenotypes in naturally aged rats;Journal of Translational Medicine;2024-08-05

3. Rejuvenation of the Aging Heart: Molecular Determinants and Applications;Canadian Journal of Cardiology;2024-08

4. Crosstalk between the DNA damage response and cellular senescence drives aging and age-related diseases;Seminars in Immunopathology;2024-08

5. mtDNA release promotes cGAS-STING activation and accelerated aging of postmitotic muscle cells;Cell Death & Disease;2024-07-23