Predicting QRS and PR interval prolongations in humans using nonclinical data

Author:

Bergenholm L12ORCID,Parkinson J3,Mettetal J4,Evans N D1,Chappell M J1,Collins T4

Affiliation:

1. Biomedical and Biological Systems Laboratory, School of Engineering; University of Warwick; Coventry UK

2. Drug Metabolism and Pharmacokinetics, Cardiovascular and Metabolic Diseases; Innovative Medicines and Early Development, AstraZeneca; Gothenburg Sweden

3. Early Clinical Development, Quantitative Clinical Pharmacology; Innovative Medicines and Early Development, AstraZeneca; Gothenburg Sweden

4. Safety and ADME Translational Sciences, Drug Safety and Metabolism; Innovative Medicines and Early Development, AstraZeneca; Cambridge UK

Funder

Marie Curie FP7 People ITN European Industrial Doctorate (EID)

Publisher

Wiley

Subject

Pharmacology

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2. The Concise Guide to PHARMACOLOGY 2015/16: Voltage-gated ion channels;Alexander;Br J Pharmacol,2015

3. Development and validation of a 96-well equilibrium dialysis apparatus for measuring plasma protein binding;Banker;J Pharm Sci,2003

4. The mechanism of flecainide action in CPVT does not involve a direct effect on RyR2;Bannister;Circ Res,2015

5. PKPD modelling of PR and QRS intervals in conscious dogs using standard safety pharmacology data;Bergenholm;J Pharmacol Toxicol Methods,2016

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