1. From the Institute of Molecular and Experimental Medicine, Wales Heart Research Institute, Cardiff University School of Medicine, Cardiff, United Kingdom (M.L.B., N.L.T., S.M., C.M., C.H.G., A.J.W.); and Myocardial Function Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom (M.B.S., K.T.M.).