VU0810464, a non‐urea G protein‐gated inwardly rectifying K + (K ir 3/GIRK) channel activator, exhibits enhanced selectivity for neuronal K ir 3 channels and reduces stress‐induced hyperthermia in mice

Author:

Vo Baovi N.1,Abney Kristopher K.2,Anderson Allison1,Marron Fernandez de Velasco Ezequiel1,Benneyworth Michael A.3,Daniels John Scott4,Morrison Ryan D.4,Hopkins Corey R.5,Weaver Charles David6,Wickman Kevin1ORCID

Affiliation:

1. Department of PharmacologyUniversity of Minnesota Minneapolis MN

2. School of Graduate Studies and ResearchMeharry Medical College Nashville TN

3. Department of NeuroscienceUniversity of Minnesota Minneapolis MN

4. Research and DevelopmentPrecera Bioscience, Inc. Franklin TN

5. Department of Pharmaceutical Sciences, College of PharmacyUniversity of Nebraska Medical Center Omaha NE

6. Departments of Pharmacology and ChemistryVanderbilt University Nashville TN

Funder

National Heart, Lung, and Blood Institute

National Institute of Mental Health

National Institute on Drug Abuse

Publisher

Wiley

Subject

Pharmacology

Reference57 articles.

1. Analgesic effects of the GIRK Activator, VU0466551, alone and in combination with morphine in acute and persistent pain models;Abney K. K.;ACS Chemical Neuroscience,2019

2. The stress‐induced hyperthermia paradigm as a physiological animal model for anxiety: A review of pharmacological and genetic studies in the mouse;Adriaan Bouwknecht J.;Neuroscience and Biobehavioral Reviews,2007

3. THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: G protein‐coupled receptors;Alexander S. P. H.;British Journal of Pharmacology,2017

4. THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Ligand‐gated ion channels;Alexander S. P. H.;British Journal of Pharmacology,2017

5. Expression and relevance of the G protein‐gated K+ channel in the mouse ventricle;Anderson A.;Scientific Reports,2018

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