NAP1L1-MLLT10is a rare recurrent translocation that is associated withHOXAactivation and poor treatment response in T-cell acute lymphoblastic leukaemia

Author:

Bond Jonathan12,Touzart Aurore12,Cieslak Agata12,Trinquand Amélie12,Marchand Tony3,Escoffre Martine3,Contet Audrey4,Muller Marc5,Schmitt Claudine4,Fest Thierry3,Asnafi Vahid12,Macintyre Elizabeth12

Affiliation:

1. Université Paris Descartes Sorbonne Cité; Institut Necker-Enfants Malades (INEM); Institut national de recherche médicale (INSERM) U1151; Paris France

2. Laboratory of Onco-Haematology; Assistance Publique-Hôpitaux de Paris (AP-HP); Hôpital Necker Enfants-Malades; Paris France

3. Department of Haematology; University Hospital and INSERM UMR 917; Rennes 1 University; Rennes France

4. Department of Paediatric Haematology; University Hospital; Nancy France

5. Genetics Laboratory; University Hospital; Nancy France

Funder

Kay Kendall Leukaemia Fund

Association Laurette Fugain

INCa CARAMELE Translational Research and PhD Programmes

Publisher

Wiley

Subject

Hematology

Reference10 articles.

1. Analysis of TCR, pT alpha, and RAG-1 in T-acute lymphoblastic leukemias improves understanding of early human T-lymphoid lineage commitment;Asnafi;Blood,2003

2. The prognosis of CALM-AF10-positive adult T-cell acute lymphoblastic leukemias depends on the stage of maturation arrest;Ben Abdelali;Haematologica,2013

3. Breakpoint heterogeneity in t(10;11) translocation in AML-M4/M5 resulting in fusion of AF10 and MLL is resolved by fluorescent in situ hybridization analysis;Beverloo;Cancer Research,1995

4. Cryptic XPO1-MLLT10 translocation is associated with HOXA locus deregulation in T-ALL;Bond;Blood,2014

5. New MLLT10 gene recombinations in pediatric T-acute lymphoblastic leukemia;Brandimarte;Blood,2013

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