New MLLT10 gene recombinations in pediatric T-acute lymphoblastic leukemia-Reference-Cited by-同舟云学术

New MLLT10 gene recombinations in pediatric T-acute lymphoblastic leukemia

Published:2013-06-20 Issue:25 Volume:121 Page:5064-5067
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Brandimarte Lucia¹,Pierini Valentina¹,Di Giacomo Danika¹,Borga Chiara²,Nozza Filomena¹,Gorello Paolo¹,Giordan Marco²,Cazzaniga Giovanni³,te Kronnie Geertruy²,La Starza Roberta¹,Mecucci Cristina¹

Affiliation:

1. Hematology and Bone Marrow Transplantation Unit, University of Perugia, Perugia, Italy;

2. Department of Women’s and Children’s Health, University of Padova, Padova, Italy; and

3. Centro Ricerca Tettamanti, Clinica Pediatrica, Università di Milano-Bicocca, Ospedale S. Gerardo, Monza, Italy

Abstract

Key Points In pediatric T-ALL, MLLT10 emerged as a promiscuous gene, maintaining the critical leukemogenic OM-LZ domain in all fusions. MLLT10 gene fusions were associated with a specific expression profile within the HOXA subgroup of pediatric T-ALL.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/25/5064/1367189/5064.pdf

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