Characterizing Class‐Specific Exposure‐Viral Load Suppression Response of HIV Antiretrovirals Using A Model‐Based Meta‐Analysis

Author:

Xu Y1,Li YF1,Zhang D1,Dockendorf M1,Tetteh E1,Rizk ML1,Grobler JA1,Lai M‐T1,Gobburu J2,Ankrom W1

Affiliation:

1. Merck Sharp & Dohme Corp Kenilworth New Jersey USA

2. Center of Translational Science University of Maryland School of Pharmacy Baltimore Maryland USA

Funder

Merck Sharp and Dohme

Publisher

Wiley

Subject

General Pharmacology, Toxicology and Pharmaceutics,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Neuroscience

Reference29 articles.

1. Panel on Antiretroviral Guidelines for Adults and Adolescents.Guidelines for the use of antiretroviral agents in HIV‐1‐infected adults and adolescents. Department of Health and Human Services. Available athttp://aidsinfo.nih.gov/contentfiles/lvguidelines/adultandadolescentgl.pdf. Accessed July 2014.

2. Food and Drug Administration.Guidance for Industry: Human Immunodeficiency Virus‐1 Infection: Developing Antiretroviral Drugs for Treatment. Available athttp://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/UCM355128.pdf. Accessed July 2014.

3. From in vitro EC50 to in vivo dose–response for antiretrovirals using an HIV disease model. Part I: A framework

4. From in vitro EC50 to in vivo dose–response for antiretrovirals using an HIV disease model. Part II: Application to drug development

5. Model-Based Meta-Analysis for Comparative Efficacy and Safety: Application in Drug Development and Beyond

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