Clinical Pharmacokinetics of the Novel HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitor Doravirine: An Assessment of the Effect of Patient Characteristics and Drug–Drug Interactions

Author:

Khalilieh SauzanneORCID,Yee Ka LaiORCID,Sanchez Rosa,Stoch S. Aubrey,Wenning Larissa,Iwamoto Marian

Funder

Merck Sharp & Dohme Corp

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),General Medicine

Reference108 articles.

1. UNAIDS. Global HIV & AIDS statistics-2019 fact sheet. 2019. http://www.unaids.org/en/resources/fact-sheet. Accessed 19 Aug 2019.

2. European AIDS Clinical Society. European guidelines for treatment of HIV-positive adults in Europe, version 9.1. http://www.eacsociety.org/files/2018_guidelines-9.1-english.pdf. Accessed 14 May 2019.

3. Panel on Antiretroviral Guidelines for Adults and Adolescents. Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents Living with HIV. 2018. https://aidsinfo.nih.gov/contentfiles/lvguidelines/adultandadolescentgl.pdf. Accessed 19 Aug 2019.

4. Orkin C, Squires KE, Molina JM, Sax PE, Wong WW, Sussmann O, et al. Doravirine/lamivudine/tenofovir disoproxil fumarate is non-inferior to efavirenz/emtricitabine/tenofovir disoproxil fumarate in treatment-naive adults with human immunodeficiency virus-1 infection: week 48 results of the DRIVE-AHEAD trial. Clin Infect Dis. 2019;68:535–44.

5. Molina JM, Squires K, Sax PE, Cahn P, Lombaard J, DeJesus E, et al. Doravirine versus ritonavir-boosted darunavir in antiretroviral-naive adults with HIV-1 (DRIVE-FORWARD): 48-week results of a randomised, double-blind, phase 3, non-inferiority trial. Lancet HIV. 2018;5:e211–20.

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