Unraveling the antitrypanosomal mechanism of benznidazole and related 2‐nitroimidazoles: From prodrug activation to DNA damage-Reference-Cited by-同舟云学术

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Unraveling the antitrypanosomal mechanism of benznidazole and related 2‐nitroimidazoles: From prodrug activation to DNA damage

Published:2021-06-23 Issue:2 Volume:116 Page:674-689
ISSN:0950-382X
Container-title:Molecular Microbiology
language:en
Short-container-title:Mol Microbiol

Author:

Dattani Ambika¹,Drammeh Isatou¹,Mahmood Aishah¹,Rahman Mahbubur¹,Szular Joanna¹,Wilkinson Shane R.¹^ORCID

Affiliation:

1. School of Biological & Chemical Sciences Queen Mary University of London London UK

Funder

Queen Mary University of London

Islamic Development Bank

Publisher

Wiley

Subject

Molecular Biology,Microbiology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/mmi.14763

Reference74 articles.

1. High-throughput decoding of antitrypanosomal drug efficacy and resistance

2. Tagging a T. brucei RRNA locus improves stable transfection efficiency and circumvents inducible expression position effects

3. A current analysis of chemotherapy strategies for the treatment of human African trypanosomiasis

4. Cockayne syndrome group B protein regulates DNA double‐strand break repair and checkpoint activation

5. A CRISPR Cas9 high-throughput genome editing toolkit for kinetoplastids

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1. Halicin: A New Horizon in Antibacterial Therapy against Veterinary Pathogens;Antibiotics;2024-05-27

2. Synthesis of new trypanocidal agents from the hybridisation of metronidazole and eugenol analogues;Bioorganic Chemistry;2024-05

3. Design, synthesis and antitrypanosomatid activity of 2-nitroimidazole-3,5-disubstituted isoxazole compounds based on benznidazole;European Journal of Medicinal Chemistry;2023-11

4. Fexinidazole induced cytotoxicity is distinct from related anti-trypanosome nitroaromatic drugs;2023-10-09

5. Dissecting the interstrand crosslink DNA repair system of Trypanosoma cruzi;DNA Repair;2023-05

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