Injectable simvastatin gel for minimally invasive periosteal distraction: In vitro and in vivo studies in rat

Author:

Hao Jia1ORCID,Chou Joshua23,Kuroda Shinji1,Otsuka Makoto4,Kasugai Shohei1,Lang Niklaus P.5

Affiliation:

1. Department of Oral Implantology and Regenerative Dental Medicine; Graduate School of Medical and Dental Sciences; Tokyo Medical and Dental University; Tokyo Japan

2. Division of Bone and Mineral Research; Harvard School of Dental Medicine; Boston MA USA

3. Advanced Tissue Regeneration and Drug Delivery Group; University of Technology Sydney; Ultimo NSW Australia

4. Research Institute of Pharmaceutical Science; Faculty of Pharmacy; Musashino University; Tokyo Japan

5. Implant Dentistry; Faculty of Dentistry; The University of Hong Kong; Hong Kong SAR China

Funder

Osteology Foundation

Publisher

Wiley

Subject

Oral Surgery

Reference25 articles.

1. Inositol hexakisphosphate inhibits osteoclastogenesis on RAW 264.7 cells and human primary osteoclasts;Arriero;PLoS One,2012

2. Local application of statin promotes bone repair through the suppression of osteoclasts and the enhancement of osteoblasts at bone-healing sites in rats;Ayukawa;Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology,2009

3. Complications of grafting in the atrophic edentulous or partially edentulous jaw;Bahat;International Journal of Periodontics & Restorative Dentistry,2001

4. Periosteal-derived cells for bone bioengineering: A promising candidate;Castro-Silva;Clinical Oral Implants Research,2012

5. Simvastatin promotes osteoblast viability and differentiation via Ras/Smad/Erk/BMP-2 signaling pathway;Chen;Nutrition Research,2010

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