UNBLOCK: an open-label, dose-finding, pharmacokinetic and safety study of bivalirudin in children with deep vein thrombosis

Author:

O'Brien S. H.1,Yee D. L.2,Lira J.3,Goldenberg N. A.45,Young G.3

Affiliation:

1. Division of Pediatric Hematology/Oncology; Nationwide Children's Hospital/The Ohio State University; Columbus OH USA

2. Department of Pediatrics Hematology-Oncology Section; Baylor College of Medicine; Houston TX USA

3. Hemostasis and Thrombosis Center; Children's Hospital Los Angeles; University of Southern California Keck School of Medicine; Los Angeles CA USA

4. Division of Hematology; Departments of Pediatrics and Medicine; Johns Hopkins School of Medicine; Baltimore MD USA

5. All Children's Research Institute; All Children's Hospital; Johns Hopkins Medicine; St Petersburg FL USA

Funder

National Heart, Lung, and Blood Institute

Publisher

Wiley

Subject

Hematology

Reference17 articles.

1. Current and future antithrombotic agents in children;Young;Exp Rev Cardiovasc Ther.,2004

2. Pilot dose-finding and safety study of bivalirudin in infants <6 months of age with thrombosis;Young;J Thromb Haemost,2007

3. Bivalirudin for anticoagulation in children;Rayapudi;Pediatr Blood Cancer,2008

4. Definition of clinical efficacy and safety outcomes for clinical trials in deep venous thrombosis and pulmonary embolism in children;Mitchell;J Thromb Haemost,2011

5. U.S. Department of Health and Human Services Common Terminology Criteria for Adverse Events (CTCAE) Version 4.0 evs.nci.nih.gov/ftp1/CTCAE/About.html

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