Molecular mechanism of allosteric modulation at GPCRs: insight from a binding kinetics study at the human A1adenosine receptor
Author:
Affiliation:
1. Division of Medicinal Chemistry; Leiden Academic Centre for Drug Research (LACDR); Leiden University; Leiden The Netherlands
2. Institute for Molecular Biology and Biotechnology; Free University of Brussels (VUB); Brussel Belgium
Funder
Innovational Research Incentives Scheme of the Netherlands Research Organization (NWO)
Publisher
Wiley
Subject
Pharmacology
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1111/bph.12836/fullpdf
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3. New, non-adenosine, high-potency agonists for the human adenosine A2B receptor with an improved selectivity profile compared to the reference agonist N-ethylcarboxamidoadenosine;Beukers;J Med Chem,2004
4. The allosteric enhancer, PD 81,723, stabilizes human A1 adenosine receptor coupling to G proteins;Bhattacharya;Biochim Biophys Acta,1995
5. Allosteric enhancement of adenosine A1 receptor binding and function by 2-amino-3-benzoylthiophenes;Bruns;Mol Pharmacol,1990
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